OPTIMDRUG Research Project
Centre of Excellence in Computer Assisted Systems for Drug Dosing Control and Optimisation
About the OPTIMDRUG Project
General anesthesia is a complex control problem present in various medical applications of drug management systems. It requires to mitigate risks induced by comorbidity and surgical stimulation while accommodating uncertainty in patient response and drug effects. Current practice expects the anesthesiologist to calculate and predict in real time the optimal dose to meet future events. With multiple sensing and monitoring devices, the multivariable optimization task becomes very complex for any human expert closing the loop and depends upon personal expertise, stress, fatigue, and the patient's underlying comorbidity risks. Selecting the optimal dose is a challenge due to the large size and complexity of the problem and is essential to ensure the best care and safety of the patient, to minimize complications and post-interventional risks.
Objectives
The main goal of the project is to offer a complete patient-oriented platform, along with a multi-objective algorithm, for optimal and continuous drugs infusion.
The objectives are rather ground breaking and original in content, addressing current challenges identified from recent worldwide events:
- Objective 1 aims to design and implement a software patient simulator to mimic surgical states during general anesthesia.
- Objective 2 proposes a design and implementation methodology for several control algorithms to optimize multi-drug dosing to counteract the strong dynamic interactions and reduce uncertainties.
- Objective 3 develops an integrated and trustworthy solution for computer controlled anesthesia for clinical demonstrator to create awareness and first-hand training of young professionals. The socio-economic impact of the project is foreseen in improved patient outcome, minimize risk of comorbidities for general anesthesia and overall cost reduction in post-surgery recovery. A projection beyond project timeline is to generalize to other drug dosing optimization problems in related medical areas.
OUR TEAM
Clara IONESCU
Director of the OPTIMDRUG Project, Prof. Dr. ir.
Eva H. DULF
Prof. Dr. Eng.
Cristina I. Mureșan
Prof. Dr. Eng.
Dana COPOT
Dr. ir.
Teodora Mocan
Assoc. Prof. Dr.
Lucian Mocan
Assoc. Prof. Dr.
Robert Szabo
As. Dr.
Isabela Bîrs
As. Dr. Eng.
Alex Ede Danku
MSc.Eng. (PhD student)
Noemi Lorenzovici
MSc.Eng. (PhD student)
Elisabeta KOZMA
MSc.Eng. (PhD student)
Alexandru G. Berciu
MSc.Eng. (PhD student)
News
We invite you to visit this section to find out the latest news from the OPTIMDRUG team: published articles, conferences attended or other thematic information.
We will constantly update this section!
Creating Awareness
One of the aims of the OPTIMDRUG project is also to promote the technology among medical specialists. This section will contain updated information about the steps the OPTIMDRUG team is taking in this direction!
Questionnaire
We want to hear directly from you about the medical processes you use! The time to complete the questionnaire is 10-15 minutes maximum!
Disclaimer: This work has received funding from the European Union through the National Recovery and Resilience Plan of Romania, in the field of Physical Sciences and Engineering, grant agreement No. 760068 / 23.05.2023. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union. Neither the European Union nor the granting authority can be held responsible for them.
PNRR. Finanțat de Uniunea Europeană – UrmătoareaGenerațieUE.
Conținutul acestui material nu reprezintă în mod obligatoriu poziția oficială a Uniunii Europene sau a Guvernului României.
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